ABSTRACT
Diabetes mellitus is considered to be a state of persistent low grade inflammation which contributes to the pathogenesis of disease. Inflammation is a state of local protective response to tissue injury. In addition to local response, systemic response called as acute-phase response is depicted by the changes in levels of acute phase reactants like CReactive Protein(CRP), complement system proteins, serum amyloid A, haptoglobin and fibrinogen. Methods: 50 Type 2 Diabetic patients and 50 non diabetic subjects between the age group of 30-65 years who were all attending in OPD at Santosh Medical college and Hospital Ghaziabad, were selected for the study. Results: Both the study and control groups were comparable with respect to age (p 0.012). The study group had higher body mass index(p 0.0003), higher fasting blood glucose (p<0.0001), higher 2 –hour postprandial blood glucose (p<0.0001), higher HbA1c levels (p<0.0001), higher serum total cholesterol (p<0.0001), higher triglyceride levels(p<0.0001), higher LDL cholesterol(p<0.0001), and lower HDL cholesterol levels(p<0.0001), higher hsCRP level (p<0.0001), higher MDA level (p<0.0001) and Lower Thiols level (p<0.0001) in type 2 DM subjects. Conclusion: In conclusion, the mean concentrations of fasting & postprandial serum glucose, lipids, high-sensitivity C-reactive protein, MDA, & glycated hemoglobin were significantly increased in type 2 diabetic subjects when compared to controls. There was no significant increase in plasma protein Thiols levels found in type 2 diabetic subjects when compared to controls.